| 产品名称 |
Lin28B Mouse mAb (H245） |
| 来源宿主: |
Mouse |
| 反应种属: |
Human |
| 克隆类型 |
Mouse monoclonal |
| 克隆号 |
H245 |
| 同种型 |
IgG |
| 标记 |
unconjugated |
| 纯化方式 |
Protein A affinity purified. |
| 形式 |
Liquid |
| 存储溶液 |
PBS (pH7.4),50% Glycerol,0.05% BSA,0.05% Proclin 300 |
| 存储方式 |
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles. |
| 应用 |
WB,IHC,mIHC,IF |
| 使用方法 |
WB 1:200-1:1000;IHC 1:200-1:500;mIHC 1:200-1:500;IF 1:50-1:100 |
| 有效期 |
one year |
| 别名 |
CSDD2; FLJ16517; LIN28B; Protein lin-28 homolog B; |
| 免疫原 |
Recombinant protein |
| SwissProt |
Q6ZN17 |
| 细胞定位 |
Recombinant protein |
| 分子量 |
Predicted band size: 27 kDa |
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LIN28 is thought to regulate the self-renewal of stem cells. In nematodes, the LIN28 homolog lin-28 is a heterochronic gene that determines the onset of early larval stages of developmental events in Caenorhabditis elegans, by regulating the self-renewal of nematode stem cells in the skin (called seam cells) and vulva (called VPCs) during development. In mice, LIN28 is highly expressed in mouse embryonic stem cells and during early embryogenesis.It acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Lin28B is high expression in testis, fetal liver, placenta and in hepatocellular carcinoma.
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